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M9480611.TXT
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1994-08-20
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Document 0611
DOCN M9480611
TI The association of human papillomavirus infection with balanoposthitis:
a description of five cases with proposals for treatment.
DT 9410
AU Birley HD; Luzzi GA; Walker MM; Ryait B; Taylor-Robinson D; Renton AM;
Department of Genitourinary Medicine and Communicable Disease, St;
Mary's Hospital Medical School, London, UK.
SO Int J STD AIDS. 1994 Mar-Apr;5(2):139-41. Unique Identifier : AIDSLINE
MED/94305011
AB The features and clinical course of chronic balanitis in 5 patients are
presented. In each case, histological examination of a cutaneous biopsy
sample showed pronounced features of human papillomavirus (HPV)
infection. In addition, HPV DNA was demonstrated in each biopsy specimen
by a polymerase chain reaction and was found to be type 6 by Southern
blot hybridization in 4 of the cases. Although the association of
histological features of HPV infection with balanitis does not prove
that HPV is causal, the failure to find other causes, the prolonged and
distressing symptoms, and the ineffectiveness of topical steroids in
improving symptoms, all suggest the importance of HPV infection. While
effective treatment needs to be sought and developed, the response of
one patient to oral isotretinoin suggests that this agent may be
appropriate for a larger trial.
DE Administration, Oral Administration, Topical Adult
Balanitis/*MICROBIOLOGY Biopsy Blotting, Southern Case Report DNA,
Viral/*ANALYSIS Human Isotretinoin/THERAPEUTIC USE Male
*Papillomavirus, Human/CLASSIFICATION *Papovaviridae Infections/DRUG
THERAPY Polymerase Chain Reaction Serotyping Steroids/THERAPEUTIC USE
Treatment Outcome *Tumor Virus Infections/DRUG THERAPY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).